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PATENT NOTICES

AFREZZA® (insulin human) inhalation powder, the AFREZZA® inhaler, their components, methods of use, and methods of manufacture, are covered variously by the following U.S. patents:

6,444,226

Purification and stabilization of peptide and protein pharmaceutical agents

6,652,885

Purification and stabilization of peptide and protein pharmaceutical agents

7,305,986

Unit dose capsules for use in a dry powder inhaler

7,464,706

Unit dose cartridge and dry powder inhaler

7,648,960

Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles

7,709,639

Catalysis of diketopiperazine synthesis

7,799,344

Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents

7,803,404

Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces

7,943,178

Methods and compositions for delivering peptides

7,943,572

Superior control of blood glucose in diabetes treatment

8,119,593

Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin

8,146,588

Unit dose capsules and dry powder inhaler

8,156,936

Unit dose capsules and dry powder inhaler

8,202,992

Catalysis of diketopiperazine synthesis

8,215,300

Unit dose cartridge and dry powder inhaler

8,227,409

Diketopiperazine microparticles with defined isomer contents

8,258,095

Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal content

8,389,470

Methods and compositions for delivering peptides

8,424,518

Dry powder inhaler and system for drug delivery

8,485,180

Dry powder drug delivery system

8,491,848

Reactor for producing pharmaceutical particles in a precipitation process

8,499,757

Dry powder inhaler and system for drug delivery

8,551,528

Diketopiperazine microparticles with defined specific surface areas

8,590,320

Apparatus and method for cryogranulating a pharmaceutical composition

8,623,817

Method of treating diabetes type 2 by administering ultrarapid acting insulin

8,636,001

Dry powder inhaler and system for drug delivery

8,729,019

Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents

8,734,845

Diketopiperazine microparticles with defined specific surface areas

8,778,403

Diketopiperazine microparticles with defined specific surface areas

8,889,099

Methods and Compositions for Delivering Peptides

8,912,193

Dry powder inhaler and system for drug delivery

8,925,726

Blister Package For Pharmaceutical Cartridges

8,950,397

Unit Dose Cartridge And Dry Powder Inhaler

9,061,111

9,089,497

Unit Dose Capsules and Dry Powder Inhaler

Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces

9,192,675

Dry Powder Inhaler and System for Drug Delivery

9,283,193


9,339,615    

9,346,766

9,358,352

9,393,372    

D613,849

Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents

Dry Powder Inhaler and System for Drug Delivery

Catalysis of Diketopiperazine Synthesis

Dry Powder Drug Delivery System and Methods

Dry Powder Delivery System

Cartridge for a dry powder inhaler

D614,760

Dry powder inhaler

D643,308

Blister packaging

D664,640

Cartridge for a dry powder inhaler

D671,842

Blister packaging

Other patents pending.

This list is provided in compliance with the virtual patent marking provisions of 35 USC §287.